Antifungal Characteristics of N,N'-Hexamethylenebis(4-carbamoyl-1-decylpyridinium bromide)

3-Carbamoyl-1-(2-nitrobenzyl)pyridin­ium bromide

In the title compound, C(13)H(12)N(3)O(3) (+)·Br(-), the benzene and pyridinium rings form a dihedral angle of 82.0 (1)°. In the crystal, N-H⋯Br and N-H⋯O hydrogen bonds link the components into chains along [001]. In addition, weak C-H⋯O and C-H⋯Br hydrogen bonds are observed.

5-Carbamoyl-2-methyl-1-(2-methyl­benz­yl)pyridinium bromide

In the title mol-ecular salt, C(15)H(17)N(2)O(+)·Br(-), the benzene and pyridinium rings form a dihedral angle of 83.0 (1)°. In the crystal, N-H⋯Br and N-H⋯O hydrogen bonds link the components into chains along [010]. These chains are linked by weak C-H⋯O and C-H⋯Br hydrogen bonds, forming a three-dimensional network.

Antifungal application of non - antifungal drugs 1

1-Tetra­decyl­pyridinium bromide monohydrate

In the title compound, C(19)H(34)N(+)·Br(-)·H(2)O, the dihedral angle between the trans-planar alkyl side chain and the pyridinium ring is 52.73 (7)°. In the crystal structure, O-H⋯Br, C-H⋯Br and C-H⋯O hydrogen bonds form a network, while the hydro-phobic alkyl chains inter-digitate, forming bilayers.

Antitumor activities of newly synthesized 5-carbamoyl-1 H-imidazol-4yl 1-adamantanecarboxylate and 5-carbamoyl-1H-imidazol-4yl piperonylate.

In synthetic studies on the chemical modification of the nucleoside antibiotic bredinin, two new derivatives, 5-carbamoyl-1H-imidazol-4-yl 1-adamantanecarboxylate and 5-carbamoyl-1H-imidazol-4-yl piperonylate, were found to possess a potent antitumor activity in several experimental tumor systems, even though bredinin itself shows only in vitro cytotoxicity and thus lacks therapeutic effectiven...